Mouse Hepatic Oval Cells Require Met-Dependent PI3K to Impair TGF-β-Induced Oxidative Stress and Apoptosis

We have previously shown that oval cells harboring a genetically inactivated Met tyrosine kinase (Met(−/−) oval cells) are more sensitive to TGF-β-induced apoptosis than cells expressing a functional Met (Met(flx/flx)), demonstrating that the HGF/Met axis plays a pivotal role in oval cell survival....

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Detalhes bibliográficos
Main Authors: Martínez-Palacián, Adoración, del Castillo, Gaelle, Suárez-Causado, Amileth, García-Álvaro, María, de la Morena-Frutos, Diego, Fernández, Margarita, Roncero, Cesáreo, Fabregat, Isabel, Herrera, Blanca, Sánchez, Aránzazu
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3534654/
https://ncbi.nlm.nih.gov/pubmed/23301029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0053108
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