Identification of a novel enhancer that binds Sp1 and contributes to induction of cold-inducible RNA-binding protein (cirp) expression in mammalian cells

BACKGROUND: There are a growing number of reports on the sub-physiological temperature culturing of mammalian cells for increased recombinant protein yields. However, the effect varies and the reasons for the enhancement are not fully elucidated. Expression of cold-inducible RNA-binding protein (cir...

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Main Authors: Sumitomo, Yasuhiko, Higashitsuji, Hiroaki, Higashitsuji, Hisako, Liu, Yu, Fujita, Takanori, Sakurai, Toshiharu, Candeias, Marco M, Itoh, Katsuhiko, Chiba, Tsutomu, Fujita, Jun
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3534229/
https://ncbi.nlm.nih.gov/pubmed/23046908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6750-12-72
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