IL-13 Promotes Collagen Accumulation in Crohn’s Disease Fibrosis by Down-Regulation of Fibroblast MMP Synthesis: A Role for Innate Lymphoid Cells?

BACKGROUND: Fibrosis is a serious consequence of Crohn’s disease (CD), often necessitating surgical resection. We examined the hypothesis that IL-13 may promote collagen accumulation within the CD muscle microenvironment. METHODS: Factors potentially modulating collagen deposition were examined in i...

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Bibliographic Details
Main Authors: Bailey, Jennifer R., Bland, Paul W., Tarlton, John F., Peters, Iain, Moorghen, Moganaden, Sylvester, Paul A., Probert, Christopher S. J., Whiting, Christine V.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3534115/
https://ncbi.nlm.nih.gov/pubmed/23300643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0052332
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