Leptin Induces Cyclin D1 Expression and Proliferation of Human Nucleus Pulposus Cells via JAK/STAT, PI3K/Akt and MEK/ERK Pathways

Increasing evidence suggests that obesity and aberrant proliferation of nucleus pulposus (NP) cells are associated with intervertebral disc degeneration. Leptin, a hormone with increased circulating level in obesity, has been shown to stimulate cell proliferation in a tissue-dependent manner. Nevert...

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Главные авторы: Li, Zheng, Shen, Jianxiong, Wu, William Ka Kei, Yu, Xin, Liang, Jinqian, Qiu, Guixing, Liu, Jiaming
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2012
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3534060/
https://ncbi.nlm.nih.gov/pubmed/23300886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0053176
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