B cell depletion in immune thrombocytopenia reveals splenic long-lived plasma cells

Primary immune thrombocytopenia (ITP) is a disorder caused by autoantibody-mediated platelet destruction and decreased platelet production. Rituximab, a B cell–depleting agent, has become the first-line treatment for ITP; however, patients with refractory disease usually require splenectomy. We iden...

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Main Authors: Mahévas, Matthieu, Patin, Pauline, Huetz, François, Descatoire, Marc, Cagnard, Nicolas, Bole-Feysot, Christine, Le Gallou, Simon, Khellaf, Mehdi, Fain, Olivier, Boutboul, David, Galicier, Lionel, Ebbo, Mikael, Lambotte, Olivier, Hamidou, Mohamed, Bierling, Philippe, Godeau, Bertrand, Michel, Marc, Weill, Jean-Claude, Reynaud, Claude-Agnès
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3533302/
https://ncbi.nlm.nih.gov/pubmed/23241960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI65689
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