TOPICAL ANTIHISTAMINES DISPLAY POTENT ANTI-INFLAMMATORY ACTIVITY LINKED IN PART TO ENHANCED PERMEABILITY BARRIER FUNCTION

Systemic antagonists of the histamine type 1 and 2 receptors (H1/2r) are widely used as anti-pruritics and central sedatives, but demonstrate only modest anti-inflammatory activity. Because many inflammatory dermatoses result from defects in cutaneous barrier function, and because keratinocytes expr...

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Autori principali: Lin, Tzu-Kai, Man, Mao-Qiang, Santiago, Juan-Luis, Park, Kyungho, Roelandt, Truus, Oda, Yuko, Hupe, Melanie, Crumrine, Debra, Lee, Hae-Jin, Gschwandtner, Maria, Thyssen, Jacob P., Trullas, Carles, Tschachler, Erwin, Feingold, Kenneth R., Elias, Peter M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3532566/
https://ncbi.nlm.nih.gov/pubmed/23014339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jid.2012.335
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