Proximal tubule Na(+)/H(+) exchanger activity in adult NHE8(−/−), NHE3(−/−), and NHE3(−/−)/NHE8(−/−) mice

NHE3 is the predominant Na(+)/H(+) exchanger on the brush-border membrane (BBM) of the proximal tubule in adults. However, NHE3 null mice still have significant renal BBM Na(+)/H(+) activity. NHE8 has been localized to the BBM of proximal tubules and is more highly expressed in neonates than adult a...

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Bibliographic Details
Main Authors: Baum, Michel, Twombley, Katherine, Gattineni, Jyothsna, Joseph, Catherine, Wang, Lin, Zhang, Qiuyu, Dwarakanath, Vangipuram, Moe, Orson W.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2012
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3532489/
https://ncbi.nlm.nih.gov/pubmed/23054255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00415.2012
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