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A combination of intradermal jet-injection and electroporation overcomes in vivo dose restriction of DNA vaccines

BACKGROUND: The use of optimized delivery devices has been shown to enhance the potency of DNA vaccines. However, further optimization of DNA vaccine delivery is needed for this vaccine modality to ultimately be efficacious in humans. METHODS: Herein we evaluated antigen expression and immunogenicit...

詳細記述

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書誌詳細
主要な著者: Hallengärd, David, Bråve, Andreas, Isaguliants, Maria, Blomberg, Pontus, Enger, Jenny, Stout, Richard, King, Alan, Wahren, Britta
フォーマット: Artigo
言語:Inglês
出版事項: BioMed Central 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3532290/
https://ncbi.nlm.nih.gov/pubmed/22873174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-0556-10-5
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