A combination of intradermal jet-injection and electroporation overcomes in vivo dose restriction of DNA vaccines

BACKGROUND: The use of optimized delivery devices has been shown to enhance the potency of DNA vaccines. However, further optimization of DNA vaccine delivery is needed for this vaccine modality to ultimately be efficacious in humans. METHODS: Herein we evaluated antigen expression and immunogenicit...

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Detalhes bibliográficos
Main Authors: Hallengärd, David, Bråve, Andreas, Isaguliants, Maria, Blomberg, Pontus, Enger, Jenny, Stout, Richard, King, Alan, Wahren, Britta
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3532290/
https://ncbi.nlm.nih.gov/pubmed/22873174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-0556-10-5
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