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SnoN/SkiL Expression is Modulated via Arsenic Trioxide-Induced Activation of the PI3K/AKT Pathway in Ovarian Cancer Cells

SnoN/SkiL (TGFβ regulator) is dysregulated in ovarian cancer, a disease associated with acquired drug-resistance. Arsenic trioxide (As(2)O(3)used in treating APL) induces SnoN to oppose the apoptotic response in ovarian cancer cells. We now report that As(2)O(3) increases phosphorylation of EGFR/p66...

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Detalhes bibliográficos
Main Authors: Kodigepalli, Karthik M, Dutta, Punashi S, Bauckman, Kyle A, Nanjundan, Meera
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3531974/
https://ncbi.nlm.nih.gov/pubmed/23178716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2012.11.003
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