Intravenous delivery of AAV9 vector mediates effective gene expression in ischemic stroke lesion and brain angiogenic foci

BACKGROUND AND PURPOSE: Adeno-associated viral vector (AAV) is a powerful tool for delivering genes to treat brain diseases. Intravenous delivery of a self-complementary, but not single-stranded, AAV9 vector (ssAAV9) mediates robust gene expression in the adult brain. We tested if ssAAV9 effectively...

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Bibliographic Details
Main Authors: Shen, Fanxia, Kuo, Robert, Milon-Camus, Marine, Han, Zhenying, Jiang, Lidan, Young, William L., Su, Hua
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3531817/
https://ncbi.nlm.nih.gov/pubmed/23250995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/STROKEAHA.112.662965
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