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Peptide Derived from HIV-1 TAT Protein Destabilizes a Monolayer of Endothelial Cells in an in Vitro Model of the Blood-Brain Barrier and Allows Permeation of High Molecular Weight Proteins

Most chemotherapeutic agents are blood-brain barrier (BBB) impermeants. HIV-1-derived TAT protein variants contain a transmembrane domain, which may enable them to cross the BBB and reach the brain. Here we synthesized CAYGRKKRRQRRR, a peptide containing a cysteine moiety attached to the N terminus...

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מידע ביבליוגרפי
Main Authors: Cooper, Itzik, Sasson, Keren, Teichberg, Vivian I., Schnaider-Beeri, Michal, Fridkin, Mati, Shechter, Yoram
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2012
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3531782/
https://ncbi.nlm.nih.gov/pubmed/23150670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.395384
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