Differential Arabinan Capping of Lipoarabinomannan Modulates Innate Immune Responses and Impacts T Helper Cell Differentiation

Toll-like receptors (TLRs) recognize pathogens by interacting with pathogen-associated molecular patterns, such as the phosphatidylinositol-based lipoglycans, lipomannan (LM) and lipoarabinomannan (LAM). Such structures are present in several pathogens, including Mycobacterium tuberculosis, being im...

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Autors principals: Mishra, Arun K., Alves, Joana E., Krumbach, Karin, Nigou, Jerome, Castro, António G., Geurtsen, Jeroen, Eggeling, Lothar, Saraiva, Margarida, Besra, Gurdyal S.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2012
Matèries:
Immunology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3531733/
https://ncbi.nlm.nih.gov/pubmed/23144457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.402396
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