Metformin Regulates Glucose Transporter 4 (GLUT4) Translocation through AMP-activated Protein Kinase (AMPK)-mediated Cbl/CAP Signaling in 3T3-L1 Preadipocyte Cells

Metformin is a leading oral anti-diabetes mellitus medication and is known to stimulate GLUT4 translocation. However, the mechanism by which metformin acts is still largely unknown. Here, we showed that short time treatment with metformin rapidly increased phosphorylation of Cbl in an AMP-activated...

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Detalhes bibliográficos
Main Authors: Lee, Jung Ok, Lee, Soo Kyung, Kim, Ji Hae, Kim, Nami, You, Ga Young, Moon, Ji Wook, Kim, Su Jin, Park, Sun Hwa, Kim, Hyeon Soo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3531728/
https://ncbi.nlm.nih.gov/pubmed/23135276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.361386
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