MicroRNA-146a-mediated downregulation of IRAK1 protects mouse and human small intestine against ischemia/reperfusion injury

Intestinal ischemia/reperfusion (I/R) injury causes inflammation and tissue damage and is associated with high morbidity and mortality. Uncontrolled activation of the innate immune system through toll-like receptors (Tlr) plays a key role in I/R-mediated tissue damage but the underlying mechanisms h...

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Main Authors: Chassin, Cécilia, Hempel, Cordelia, Stockinger, Silvia, Dupont, Aline, Kübler, Joachim F, Wedemeyer, Jochen, Vandewalle, Alain, Hornef, Mathias W
Formato: Artigo
Idioma:Inglês
Publicado em: WILEY-VCH Verlag 2012
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3531605/
https://ncbi.nlm.nih.gov/pubmed/23143987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201201298
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