Deletion of Parasite Immune Modulatory Sequences Combined with Immune Activating Signals Enhances Vaccine Mediated Protection against Filarial Nematodes

BACKGROUND: Filarial nematodes are tissue-dwelling parasites that can be killed by Th2-driven immune effectors, but that have evolved to withstand immune attack and establish chronic infections by suppressing host immunity. As a consequence, the efficacy of a vaccine against filariasis may depend on...

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Bibliografiska uppgifter
Huvudupphovsmän: Babayan, Simon A., Luo, HongLin, Gray, Nick, Taylor, David W., Allen, Judith E.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2012
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3531514/
https://ncbi.nlm.nih.gov/pubmed/23301106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0001968
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