Anti-HIV-1 Activity of Elafin Depends on Its Nuclear Localization and Altered Innate Immune Activation in Female Genital Epithelial Cells

Elafin (E) and its precursor trappin-2 (Tr) are alarm antiproteases with antimicrobial and immunomodulatory activities. Tr and E (Tr/E) have been associated with HIV-1 resistance. We recently showed that Tr/E reduced IL-8 secretion and NF-κB activation in response to a mimic of viral dsRNA and contr...

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Main Authors: Drannik, Anna G., Nag, Kakon, Yao, Xiao-Dan, Henrick, Bethany M., Ball, T. Blake, Plummer, Francis A., Wachihi, Charles, Kimani, Joshua, Rosenthal, Kenneth L.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3531372/
https://ncbi.nlm.nih.gov/pubmed/23300756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0052738
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