Phosphodiesterase-5 Inhibition in Diastolic Heart Failure: The RELAX Trial Rationale and Design

Heart failure (HF) with preserved ejection fraction (HFpEF) or “diastolic HF” accounts for approximately half of HF cases. To date, neurohumoral antagonists have failed to show a significant benefit on clinical outcomes in HFpEF. While our understanding of the pathophysiology of HFpEF continues to d...

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Detalhes bibliográficos
Main Authors: Redfield, MM, Borlaug, BA, Lewis, GD, Mohammed, SF, Semigran, MJ, LeWinter, MM, Deswal, A, Hernandez, AF, Lee, KL, Braunwald, E
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3530955/
https://ncbi.nlm.nih.gov/pubmed/22991405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCHEARTFAILURE.112.969071
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