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The anti-viral factor APOBEC3G enhances natural killer cell recognition of HIV-infected primary T cells
APOBEC3G (A3G) is an intrinsic antiviral factor that inhibits HIV replication by deaminating cytidine residues to uridine. This causes G-to-A hypermutation in the opposite strand and results in viral inactivation. HIV counteracts A3G through the activity of viral infectivity factor (Vif), which prom...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3530928/ https://ncbi.nlm.nih.gov/pubmed/21874023 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2087 |
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