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PAK1 IS A NOVEL MEK-INDEPENDENT RAF TARGET CONTROLLING EXPRESSION OF THE IAP SURVIVIN IN M-CSF-MEDIATED OSTEOCLAST SURVIVAL

As activation of the Ras/Raf/MEK/ERK pathway is a critical component of M-CSF-promoted osteoclast survival, determining specific mechanism by which M-CSF activates this signal transduction pathway is paramount towards advancing treatment of pathological conditions resulting in increased bone turnove...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Bradley, Elizabeth W., Ruan, Ming M., Oursler, Merry J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2008
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3530845/
https://ncbi.nlm.nih.gov/pubmed/18668521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.21550
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