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PAK1 IS A NOVEL MEK-INDEPENDENT RAF TARGET CONTROLLING EXPRESSION OF THE IAP SURVIVIN IN M-CSF-MEDIATED OSTEOCLAST SURVIVAL
As activation of the Ras/Raf/MEK/ERK pathway is a critical component of M-CSF-promoted osteoclast survival, determining specific mechanism by which M-CSF activates this signal transduction pathway is paramount towards advancing treatment of pathological conditions resulting in increased bone turnove...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2008
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3530845/ https://ncbi.nlm.nih.gov/pubmed/18668521 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.21550 |
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