Local Administration of Soluble CD40:Fc to the Salivary Glands of Non-Obese Diabetic Mice Does Not Ameliorate Autoimmune Inflammation

OBJECTIVE: CD40–CD154 (CD40 ligand) interaction in the co-stimulatory pathway is involved in many (auto)immune processes and both molecules are upregulated in salivary glands of Sjögren’s syndrome (SS) patients. Interference within the CD40 pathway has ameliorated (auto)inflammation in a number of d...

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Hauptverfasser: Roescher, Nienke, Vosters, Jelle L., Lai, Zhenan, Uede, Toshimitsu, Tak, Paul P., Chiorini, John A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2012
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3530540/
https://ncbi.nlm.nih.gov/pubmed/23300544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0051375
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