HYPERTENSION INDUCES BRAIN β-AMYLOID ACCUMULATION, COGNITIVE IMPAIRMENT AND MEMORY DETERIORATION THROUGH ACTIVATION OF RAGE IN BRAIN VASCULATURE

Although epidemiological data associate hypertension with a strong predisposition to develop Alzheimer’s Disease, no mechanistic explanation exists so far. We developed a model of hypertension, obtained by Transverse Aortic Constriction, leading to alterations typical of Alzheimer’s Disease, such as...

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Main Authors: Carnevale, Daniela, Mascio, Giada, D’Andrea, Ivana, Fardella, Valentina, Bell, Robert D., Branchi, Igor, Pallante, Fabio, Zlokovic, Berislav, Yan, Shirley ShiDu, Lembo, Giuseppe
Format: Artigo
Jezik:Inglês
Izdano: 2012
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3530195/
https://ncbi.nlm.nih.gov/pubmed/22615109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.112.195511
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