Multiple autism-linked genes mediate synapse elimination via proteasomal degradation of a synaptic scaffold PSD-95

The activity-dependent transcription factor, Myocyte Enhancer Factor-2 (MEF2), induces excitatory synapse elimination in mouse neurons which requires Fragile X Mental Retardation Protein (FMRP), an RNA binding protein implicated in human cognitive dysfunction and autism. We report here that protocad...

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Autors principals: Tsai, Nien-Pei, Wilkerson, Julia R., Guo, Weirui, Maksimova, Marina A., DeMartino, George N., Cowan, Christopher W., Huber, Kimberly M.
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3530171/
https://ncbi.nlm.nih.gov/pubmed/23260144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.11.040
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