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A cell-based fascin bioassay identifies compounds with potential anti-metastasis or cognition-enhancing functions
The actin-bundling protein fascin is a key mediator of tumor invasion and metastasis and its activity drives filopodia formation, cell-shape changes and cell migration. Small-molecule inhibitors of fascin block tumor metastasis in animal models. Conversely, fascin deficiency might underlie the patho...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Company of Biologists Limited
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3529353/ https://ncbi.nlm.nih.gov/pubmed/22917928 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.008243 |
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