1-(1-Acetyl-piperidin-4-yl)-3-adamantan-1-yl-urea (AR9281) as a potent, selective, and orally available soluble epoxide hydrolase inhibitor with efficacy in rodent models of hypertension and dysglycemia

1-(1-Acetyl-piperidin-4-yl)-3-adamantan-1-yl-urea 14a (AR9281), a potent and selective soluble epoxide hydrolase inhibitor, was recently tested in a phase 2a clinical setting for its effectiveness in reducing blood pressure and improving insulin-resistance in pre-diabetic patients. In a mouse model...

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Detalhes bibliográficos
Main Authors: Anandan, Sampath-Kumar, Webb, Heather Kay, Chen, Dawn, Wang, Yi-Xin (Jim), Aavula, Basker R., Cases, Sylvaine, Cheng, Ying, Do, Zung N., Mehra, Upasana, Tran, Vinh, Vincelette, Jon, Waszczuk, Joanna, White, Kathy, Wong, Kenneth R., Zhang, Le-Ning, Jones, Paul D., Hammock, Bruce D., Patel, Dinesh V., Whitcomb, Randall, MacIntyre, D. Euan, Sabry, James, Gless, Richard
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3529200/
https://ncbi.nlm.nih.gov/pubmed/21211973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2010.12.042
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