Reduced axonal localization of a Caps2 splice variant impairs axonal release of BDNF and causes autistic-like behavior in mice

Ca(2)(+)-dependent activator protein for secretion 2 (CAPS2 or CADPS2) potently promotes the release of brain-derived neurotrophic factor (BDNF). A rare splicing form of CAPS2 with deletion of exon3 (dex3) was identified to be overrepresented in some patients with autism. Here, we generated Caps2-de...

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Detalhes bibliográficos
Main Authors: Sadakata, Tetsushi, Shinoda, Yo, Oka, Megumi, Sekine, Yukiko, Sato, Yumi, Saruta, Chihiro, Miwa, Hideki, Tanaka, Mika, Itohara, Shigeyoshi, Furuichi, Teiichi
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3529019/
https://ncbi.nlm.nih.gov/pubmed/23213205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1210055109
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