Hypertension-Linked Mutation of α-Adducin Increases CFTR Surface Expression and Activity in HEK and Cultured Rat Distal Convoluted Tubule Cells

The CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) activity and localization are influenced by the cytoskeleton, in particular by actin and its polymerization state. In this study we investigated whether the expression of the hypertensive mutations of α-adducin (G460W-S586C in humans, F3...

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Detalhes bibliográficos
Main Authors: Mondini, Anna, Sassone, Francesca, Civello, Davide Antonio, Garavaglia, Maria Lisa, Bazzini, Claudia, Rodighiero, Simona, Vezzoli, Valeria, Conti, Fabio, Torielli, Lucia, Capasso, Giovanbattista, Paulmichl, Markus, Meyer, Giuliano
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3528715/
https://ncbi.nlm.nih.gov/pubmed/23284854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0052014
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