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ZP123 Reduces Energy Required for Defibrillation by Preventing Connexin43 Remodeling during Prolonged Ventricular Fibrillation in Swine
In ventricular fibrillation, the uncoupling of gap junctions slows conduction velocity and increases action-potential dispersion, which slows and diminishes defibrillation. We studied how the peptide ZP123, a gap-junction enhancer, might lower defibrillation-energy requirements during ventricular fi...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Texas Heart Institute
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3528250/ https://ncbi.nlm.nih.gov/pubmed/23304014 |
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