The Structure of Sec12 Implicates Potassium Ion Coordination in Sar1 Activation

Coat protein II (COPII)-coated vesicles transport proteins and lipids from the endoplasmic reticulum to the Golgi. Crucial for the initiation of COPII coat assembly is Sec12, a guanine nucleotide exchange factor responsible for activating the small G protein Sar1. Once activated, Sar1/GTP binds to e...

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Bibliographic Details
Main Authors: McMahon, Conor, Studer, Sean M., Clendinen, Chaevia, Dann, Geoffrey P., Jeffrey, Philip D., Hughson, Frederick M.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2012
Subjects:
Cell Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3527946/
https://ncbi.nlm.nih.gov/pubmed/23109340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.420141
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