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The Structure of Sec12 Implicates Potassium Ion Coordination in Sar1 Activation
Coat protein II (COPII)-coated vesicles transport proteins and lipids from the endoplasmic reticulum to the Golgi. Crucial for the initiation of COPII coat assembly is Sec12, a guanine nucleotide exchange factor responsible for activating the small G protein Sar1. Once activated, Sar1/GTP binds to e...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3527946/ https://ncbi.nlm.nih.gov/pubmed/23109340 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.420141 |
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