Human Fibroblast Interferon for Clinical Trials: Pharmacokinetics and Tolerability in Experimental Animals and Humans

Human fibroblast interferon (F-interferon) purified by adsorption on controlled-pore glass was given intramuscularly to patients at daily dosages of up to 20 × 10(6) units. Serum levels of antiviral activity were low or undetectable. In contrast, reasonably high serum titers were found in patients r...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Billiau, Alfons, De Somer, Piet, Edy, Victor G., De Clercq, Erik, Heremans, Hubertine
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 1979
Subjects:
Pharmacology and Therapeutics
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC352788/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/475375/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.16.1.56
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