Pre-emptive hypoxia-regulated HO-1 gene therapy improves post-ischaemic limb perfusion and tissue regeneration in mice

AIMS: Haem oxygenase-1 (HO-1) is a haem-degrading enzyme that generates carbon monoxide, bilirubin, and iron ions. Through these compounds, HO-1 mitigates cellular injury by exerting antioxidant, anti-apoptotic, and anti-inflammatory effects. Here, we examined the influence of HO-1 deficiency and tr...

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Detalhes bibliográficos
Main Authors: Jazwa, Agnieszka, Stepniewski, Jacek, Zamykal, Martin, Jagodzinska, Jolanta, Meloni, Marco, Emanueli, Costanza, Jozkowicz, Alicja, Dulak, Jozef
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2013
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3527762/
https://ncbi.nlm.nih.gov/pubmed/23087099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvs284
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