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Oral Squamous Carcinoma Cells Secrete RANKL Directly Supporting Osteolytic Bone Loss
OBJECTIVE: Local invasion of bone is a frequent complication of oral squamous cell carcinoma (OSCC). Development of these osteolytic lesions is mediated by osteoclasts. Receptor activation of NF- B ligand (RANKL) signaling, counteracted by osteoprotegerin (OPG), regulates osteoclastogenesis. Previou...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3527639/ https://ncbi.nlm.nih.gov/pubmed/22989723 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.oraloncology.2012.08.004 |
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