Cyclooxygenase/lipoxygenase shunting lowers the anti-cancer effect of cyclooxygenase-2 inhibition in colorectal cancer cells

BACKGROUND: Arachidonic acid metabolite, generated by cyclooxygenase (COX), is implicated in the colorectal cancer (CRC) pathogenesis. Inhibiting COX may therefore have anti-carcinogenic effects. Results from use of non-steroidal anti-inflammatory drugs inhibiting only COX have been conflicting. It...

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Bibliografiske detaljer
Main Authors: Ganesh, Radhakrishnan, Marks, Daniel JB, Sales, Kevin, Winslet, Marc C, Seifalian, Alexander M
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2012
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3527267/
https://ncbi.nlm.nih.gov/pubmed/23013454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1477-7819-10-200
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