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Engineered variants of InlB with an additional leucine-rich repeat discriminate between physiologically relevant and packing contacts in crystal structures of the InlB:MET complex

The physiological relevance of contacts in crystal lattices often remains elusive. This was also the case for the complex between the invasion protein internalin B (InlB) from Listeria monocytogenes and its host cell receptor, the human receptor tyrosine kinase (RTK) MET. InlB is a MET agonist and i...

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Autors principals: Niemann, Hartmut H, Gherardi, Ermanno, Bleymüller, Willem M, Heinz, Dirk W
Format: Artigo
Idioma:Inglês
Publicat: Wiley Subscription Services, Inc., A Wiley Company 2012
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3526994/
https://ncbi.nlm.nih.gov/pubmed/22887347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2142
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