Cholesterol Modulates Cell Signaling and Protein Networking by Specifically Interacting with PDZ Domain-Containing Scaffold Proteins

Cholesterol is known to modulate the physical properties of cell membranes but its direct involvement in cellular signaling has not been thoroughly investigated. Here we show that cholesterol specifically binds many PDZ domains found in scaffold proteins, including the N-terminal PDZ domain of NHERF...

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Main Authors: Sheng, Ren, Chen, Yong, Gee, Heon Yung, Stec, Ewa, Melowic, Heather R., Blatner, Nichole R., Tun, Moe P., Kim, Yonjung, Källberg, Morten, Fujiwara, Takahiro K., Hong, Ji Hye, Kim, Kwang Pyo, Lu, Hui, Kusumi, Akihiro, Lee, Min Goo, Cho, Wonhwa
פורמט: Artigo
שפה:Inglês
יצא לאור: 2012
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Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3526836/
https://ncbi.nlm.nih.gov/pubmed/23212378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms2221
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