Cholesterol Modulates Cell Signaling and Protein Networking by Specifically Interacting with PDZ Domain-Containing Scaffold Proteins

Cholesterol is known to modulate the physical properties of cell membranes but its direct involvement in cellular signaling has not been thoroughly investigated. Here we show that cholesterol specifically binds many PDZ domains found in scaffold proteins, including the N-terminal PDZ domain of NHERF...

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Bibliografski detalji
Glavni autori: Sheng, Ren, Chen, Yong, Gee, Heon Yung, Stec, Ewa, Melowic, Heather R., Blatner, Nichole R., Tun, Moe P., Kim, Yonjung, Källberg, Morten, Fujiwara, Takahiro K., Hong, Ji Hye, Kim, Kwang Pyo, Lu, Hui, Kusumi, Akihiro, Lee, Min Goo, Cho, Wonhwa
Format: Artigo
Jezik:Inglês
Izdano: 2012
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3526836/
https://ncbi.nlm.nih.gov/pubmed/23212378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms2221
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