Cardiac Structural and Sarcomere Genes Associated with Cardiomyopathy Exhibit Marked Intolerance of Genetic Variation

BACKGROUND: The clinical significance of variants in genes associated with inherited cardiomyopathies can be difficult to determine due to uncertainty regarding population genetic variation and a surprising amount of tolerance of the genome even to loss of function variants. We hypothesized that gen...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Pan, Stephen, Caleshu, Colleen A., Dunn, Kyla E., Foti, Marcia J., Moran, Maura K., Soyinka, Oretunlewa, Ashley, Euan A.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2012
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3526690/
https://ncbi.nlm.nih.gov/pubmed/23074333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCGENETICS.112.963421
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