Rationally re-designed mutation of NAD-independent l-lactate dehydrogenase: high optical resolution of racemic mandelic acid by the engineered Escherichia coli

BACKGROUND: NAD-independent l-lactate dehydrogenase (l-iLDH) from Pseudomonas stutzeri SDM can potentially be used for the kinetic resolution of small aliphatic 2-hydroxycarboxylic acids. However, this enzyme showed rather low activity towards aromatic 2-hydroxycarboxylic acids. RESULTS: Val-108 of...

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Bibliografiske detaljer
Main Authors: Jiang, Tianyi, Gao, Chao, Dou, Peipei, Ma, Cuiqing, Kong, Jian, Xu, Ping
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2012
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3526519/
https://ncbi.nlm.nih.gov/pubmed/23176608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2859-11-151
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