The P2X(7) loss-of-function Glu496Ala polymorphism affects ex vivo cytokine release and protects against the cytotoxic effects of high ATP-levels

BACKGROUND: The P2X(7) receptor plays an important role in cytokine release during the inflammatory response in vivo. Polymorphisms within the P2X(7) receptor gene that lead to loss of receptor function may contribute to impaired cytokine release by immune cells. Therefore, we investigated whether a...

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Hlavní autoři: Wesselius, Anke, Bours, Martijn JL, Arts, Ilja CW, Theunisz, Esther HE, Geusens, Piet, Dagnelie, Pieter C
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2012
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3526505/
https://ncbi.nlm.nih.gov/pubmed/23210974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2172-13-64
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