The extent of sequence complementarity correlates with the potency of cellular miRNA-mediated restriction of HIV-1

MicroRNAs (miRNAs) are 22-nt non-coding RNAs involved in the regulation of cellular gene expression and potential cellular defense against viral infection. Using in silico analyses, we predicted target sites for 22 human miRNAs in the HIV genome. Transfection experiments using synthetic miRNAs showe...

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Detalhes bibliográficos
Main Authors: Houzet, Laurent, Klase, Zachary, Yeung, Man Lung, Wu, Annie, Le, Shu-Yun, Quiñones, Mariam, Jeang, Kuan-Teh
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2012
Assuntos:
RNA
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3526334/
https://ncbi.nlm.nih.gov/pubmed/23042677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks912
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