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Hundreds of conserved non-coding genomic regions are independently lost in mammals

Conserved non-protein-coding DNA elements (CNEs) often encode cis-regulatory elements and are rarely lost during evolution. However, CNE losses that do occur can be associated with phenotypic changes, exemplified by pelvic spine loss in sticklebacks. Using a computational strategy to detect complete...

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Bibliographic Details
Main Authors: Hiller, Michael, Schaar, Bruce T., Bejerano, Gill
Format: Artigo
Language:Inglês
Published: Oxford University Press 2012
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3526296/
https://ncbi.nlm.nih.gov/pubmed/23042682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks905
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