Stress-Induced Phosphorylation and Proteasomal Degradation of Mitofusin 2 Facilitates Mitochondrial Fragmentation and Apoptosis

Mitochondria play central roles in integrating pro- and anti-apoptotic stimuli and JNK is well-known to have roles in activating apoptotic pathways. We establish a critical link between stress-induced JNK activation, mitofusin 2, which is an essential component of the mitochondrial outer membrane fu...

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Detalhes bibliográficos
Main Authors: Leboucher, Guillaume P., Tsai, Yien Che, Yang, Mei, Shaw, Kristin C., Zhou, Ming, Veenstra, Timothy D., Glickman, Michael H., Weissman, Allan M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3526191/
https://ncbi.nlm.nih.gov/pubmed/22748923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2012.05.041
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