Computational Design of an α-Gliadin Peptidase

[Image: see text] The ability to rationally modify enzymes to perform novel chemical transformations is essential for the rapid production of next-generation protein therapeutics. Here we describe the use of chemical principles to identify a naturally occurring acid-active peptidase, and the subsequ...

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Bibliographic Details
Main Authors: Gordon, Sydney R., Stanley, Elizabeth J., Wolf, Sarah, Toland, Angus, Wu, Sean J., Hadidi, Daniel, Mills, Jeremy H., Baker, David, Pultz, Ingrid Swanson, Siegel, Justin B.
Format: Artigo
Language:Inglês
Published: American Chemical Society 2012
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3526107/
https://ncbi.nlm.nih.gov/pubmed/23153249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja3094795
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