Autocrine Function of Aldehyde Dehydrogenase 1 as a Determinant of Diet- and Sex-Specific Differences in Visceral Adiposity

Mechanisms for sex- and depot-specific fat formation are unclear. We investigated the role of retinoic acid (RA) production by aldehyde dehydrogenase 1 (Aldh1a1, -a2, and -a3), the major RA-producing enzymes, on sex-specific fat depot formation. Female Aldh1a1(−/−) mice, but not males, were resistan...

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Detalhes bibliográficos
Main Authors: Yasmeen, Rumana, Reichert, Barbara, Deiuliis, Jeffrey, Yang, Fangping, Lynch, Alisha, Meyers, Joseph, Sharlach, Molly, Shin, Sangsu, Volz, Katharina S., Green, Kari B., Lee, Kichoon, Alder, Hansjuerg, Duester, Gregg, Zechner, Rudolf, Rajagopalan, Sanjay, Ziouzenkova, Ouliana
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2013
Assuntos:
Obesity Studies
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3526050/
https://ncbi.nlm.nih.gov/pubmed/22933113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-1779
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