Per2 Mutation Recapitulates the Vascular Phenotype of Diabetes in the Retina and Bone Marrow

In this study, we assessed whether Per2 clock gene–mutant mice exhibit a vascular phenotype similar to diabetes. Per2 (B6.129-Per2(tm1Drw)/J) or wild-type control mice 4 and 12 months of age were used. To evaluate diabetes-like phenotype in Per2 mutant mice, retina was quantified for mRNA expression...

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Main Authors: Bhatwadekar, Ashay D., Yan, Yuanqing, Qi, Xiaoping, Thinschmidt, Jeffrey S., Neu, Matthew B., Li Calzi, Sergio, Shaw, Lynn C., Dominiguez, James M., Busik, Julia V., Lee, Choogon, Boulton, Michael E., Grant, Maria B.
Format: Artigo
Jezik:Inglês
Izdano: American Diabetes Association 2013
Teme:
Complications
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3526035/
https://ncbi.nlm.nih.gov/pubmed/23193187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db12-0172
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