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Crystal structure of the dimeric coiled-coil domain of the cytosolic nucleic acid sensor LRRFIP1
LRRFIP1 binds cytoplasmic double-stranded DNA and RNA and interacts with FLI, the mammalian homolog of Drosophila flightless I, through a highly conserved 87-amino acid domain. Upon binding nucleic acid ligands, LRRFIP1 recruits and activates β-catenin, leading to the IRF3-dependent production of ty...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3525766/ https://ncbi.nlm.nih.gov/pubmed/23099021 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsb.2012.10.006 |
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