SLC22A1-ABCB1 Haplotype Profiles Predict Imatinib Pharmacokinetics in Asian Patients with Chronic Myeloid Leukemia

OBJECTIVE: This study aimed to explore the influence of SLC22A1, PXR, ABCG2, ABCB1 and CYP3A5*3 genetic polymorphisms on imatinib mesylate (IM) pharmacokinetics in Asian patients with chronic myeloid leukemia (CML). PATIENTS AND METHODS: Healthy subjects belonging to three Asian populations (Chinese...

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Hlavní autoři: Singh, Onkar, Chan, Jason Yongsheng, Lin, Keegan, Heng, Charles Chuah Thuan, Chowbay, Balram
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2012
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3525665/
https://ncbi.nlm.nih.gov/pubmed/23272163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0051771
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