Generation of Superoxide Anions and Hydrogen Peroxide from β-Lapachone in Bacteria

β-Lapachone markedly increased the generation of superoxide anions and hydrogen peroxide by subcellular membranes of Bacillus subtilis and Bacillus stearothermophilus. Peroxide generation by β-lapachone was parallel to the inhibition of growth in both microorganisms.

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Cruz, Fernando S., Docampo, Roberto, Boveris, Alberto
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 1978
Subjects:
Biosynthesis; Chemistry; Mechanisms of Action and Resistance
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC352520/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/214029/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.14.4.630
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