Effect of Enzymatic Adenylylation on Dihydrostreptomycin Accumulation in Escherichia coli Carrying an R-Factor: Model Explaining Aminoglycoside Resistance by Inactivating Mechanisms

Strains of Escherichia coli carrying R-factor R71(a), which codes for a streptomycin-spectinomycin adenylyltransferase, have elevated levels of resistance to dihydrostreptomycin (DHS) compared with isogenic R(−) bacteria. DHS accumulated by whole cells and spheroplasts of R(+) bacteria is lower than...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Dickie, P., Bryan, L. E., Pickard, M. A.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1978
Soggetti:	Biosynthesis; Chemistry; Mechanisms of Action and Resistance
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC352509/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/82422/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.14.4.569
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