Effect of Enzymatic Adenylylation on Dihydrostreptomycin Accumulation in Escherichia coli Carrying an R-Factor: Model Explaining Aminoglycoside Resistance by Inactivating Mechanisms

Strains of Escherichia coli carrying R-factor R71(a), which codes for a streptomycin-spectinomycin adenylyltransferase, have elevated levels of resistance to dihydrostreptomycin (DHS) compared with isogenic R(−) bacteria. DHS accumulated by whole cells and spheroplasts of R(+) bacteria is lower than...

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Bibliographic Details
Main Authors: Dickie, P., Bryan, L. E., Pickard, M. A.
Format: Artigo
Language:Inglês
Published: 1978
Subjects:
Biosynthesis; Chemistry; Mechanisms of Action and Resistance
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC352509/
https://ncbi.nlm.nih.gov/pubmed/82422
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