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Doxorubicin blocks proliferation of cancer cells through proteolytic activation of CREB3L1

Doxorubicin is used extensively for chemotherapy of diverse types of cancer, yet the mechanism through which it inhibits proliferation of cancer cells remains unclear. Here we report that doxorubicin stimulates de novo synthesis of ceramide, which in turn activates CREB3L1, a transcription factor sy...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Denard, Bray, Lee, Ching, Ye, Jin
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: eLife Sciences Publications, Ltd 2012
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3524649/
https://ncbi.nlm.nih.gov/pubmed/23256041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.00090
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