Apoptotic-induced cleavage shifts HuR from being a promoter of survival to an activator of caspase-mediated apoptosis

Little is known about the cellular mechanisms modulating the shift in balance from a state of survival to cell death by caspase-mediated apoptosis in response to a lethal stress. Here we show that the RNA-binding protein HuR has an important function in mediating this switch. During caspase-mediated...

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Detalhes bibliográficos
Main Authors: von Roretz, C, Jin Lian, X, Macri, A M, Punjani, N, Clair, E, Drouin, O, Dormoy-Raclet, V, Ma, J F, Gallouzi, I-E
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3524645/
https://ncbi.nlm.nih.gov/pubmed/22955946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2012.111
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